A randomized trial of daclatasvir in combination with asunaprevir and beclabuvir in patients with chronic hepatitis C virus genotype 4 infection.
نویسندگان
چکیده
LB-7. Tarek Hassanein1,⇑ Karen D. Sims Michael Bennett Norman Gitlin Eric Lawitz Tuan Nguyen Lynn Webster Zobair Younossi Howard Schwartz Paul J. Thuluvath 11 non-financial support from AbbVie, Achillion, BioCryst, Biotica, Enanta, Gilead Sciences, Idenix, Janssen, Kadmon, Merck, Novartis, Presidio, Santaris, Theravance, and Vertex. L. Webster has received consulting fees from AcelRx, Acura, AstraZeneca, BioDelivery Sciences International, Boehringer Ingelheim, Boston Scientific, and Collegium. Z. Younossi has received consulting fees from Salix, Janssen, Vertex, Gilead Sciences, Enterome, and Coneatus. P.J. Thuluvath has received research grant support from Bristol-Myers Squibb, Gilead Sciences, Vertex, Isai, AbbVie, and Salix, and speaker fees from Gilead Sciences, Onyx, AbbVie, and Bayer. K.D. Sims, B. Rege, N. Zhou, M. Wind-Rotolo, E. Chung, and D.M. Grasela are employees and shareholders of Bristol-Myers Squibb. H. Zhou, F. McPhee, A. Griffies, and D.F. Gardiner are employees of Bristol-Myers Squibb. M. Bennett, N. Gitlin, T. Nguyen, and H. Schwartz have no conflicts of interest to disclose.
منابع مشابه
Fixed-dose combination therapy with daclatasvir, asunaprevir, and beclabuvir for noncirrhotic patients with HCV genotype 1 infection.
IMPORTANCE The antiviral activity of all-oral, ribavirin-free, direct-acting antiviral regimens requires evaluation in patients with chronic hepatitis C virus (HCV) infection. OBJECTIVE To determine the rates of sustained virologic response (SVR) in patients receiving the 3-drug combination of daclatasvir (a pan-genotypic NS5A inhibitor), asunaprevir (an NS3 protease inhibitor), and beclabuvi...
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BACKGROUND An unmet need exists for interferon-free and ribavirin-free treatments for chronic hepatitis C virus (HCV) infection. In this study, we assessed all-oral therapy with daclatasvir (NS5A replication complex inhibitor) plus asunaprevir (NS3 protease inhibitor) in patients with genotype 1b infection, including those with high unmet needs or cirrhosis, or both. METHODS We did this phase...
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ورودعنوان ژورنال:
- Journal of hepatology
دوره 62 5 شماره
صفحات -
تاریخ انتشار 2015